ASSOCIATION BETWEEN THE PRESENCE OF VARIOUS HLA MARKES AND SELECTED AUTOIMMUNE DISEASES IMMUNOPATHIES 

Association  entre typage HLA  et Maladies  Auto-Immunes

ASSOCIATION BETWEEN THE PRESENCE OF VARIOUS HLA MARKES AND SELECTED AUTOIMMUNE DISEASES 

ASSOCIATION BETWEEN THE PRESENCE OF VARIOUS HLA MARKES AND SELECTED AUTOIMMUNE DISEASES
DISEASEASSOCIATED HLA MARKER RELATIVE RISK OF DISEASE
Ankylosing spondylitis spa :spondylarthriteB27 87.4
Reactive arthropathy, including Reiter’s syndrome flrB27 37.0
Rheumatoid arthritis ra pr : polyarthrite rhumatoideDR 44.2
Behçet’s syndrome B51 3.8
Systemic lupus erythematosus led leadDR 35.8
Insu in-dependent (type 1) diabetes didDR 33.3
mellitusDQB1*02012.4
 D 4 6.4
DQB1*0302 9.5
DR 2 0.19
Idiopathic Addison’s disease DR 36.3
Graves’ disease DR 33.7
Hashimoto’s disease DR 113.2
Postpartum thyroiditis DR 4 5.3
Celiac disease : Maladie caeliaque DR 3 10.8
 DQB1*02016.0–10.0
DQA1*0501
DR 7, 11
DR 7, DQB1*0201
DR 11, DQA1*0501
Dermatitis herpetiformis DR 3 15.9
Sicca syndrome DR 39.7
Myasthenia gravis DR 3 2.5
B8 3.4
Idiopathic membranous g omeru- DR 312.0
Goodpasture’s syndrome DR 2 15.9
Multiple sclerosis DR 2 4.1
 DR B1*1501 
DR B5*0101
DQB1*0602
Pemphigus vulgaris (among Ash-kenazi Jews)DR 4 14.4
Psoriasis vulgaris Cw6     13.3
Birdshot retinochoroidopathy A29 109.0
   
*Symbols  with  asterisks  indicate  alleles,  and  symbols  without  asterisks
indicate  sero ogica y  defined  antigens.  For  each  disease,  the  marker  or
markers  with the strongest associations are given. In  many cases in which
it  is  difficu t  to  decide  whether  HLA-D  or  DQ markers  are  responsible
for the association, both markers are given.
†The re ative risk indicates the frequency of a disease in persons with the
HLA marker as compared with persons without the marker. A positive as-sociation (
i.e., when the HLA marker is more frequent in persons with the
disease than in those without it) is indicated by a re ative risk of more than
1.0, a negative association by a re ative risk of  ess than 1.0, and no associ-ation 
by a re ative risk of 1.0.
‡The risk has not been assessed separate y for this allele.

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