ASSOCIATION BETWEEN THE PRESENCE OF VARIOUS HLA MARKES AND SELECTED AUTOIMMUNE DISEASES IMMUNOPATHIES
Association entre typage HLA et Maladies Auto-Immunes
ASSOCIATION BETWEEN THE PRESENCE OF VARIOUS HLA MARKES AND SELECTED AUTOIMMUNE DISEASES
| DISEASE | ASSOCIATED HLA MARKER | RELATIVE RISK OF DISEASE |
| Ankylosing spondylitis spa :spondylarthrite | B27 | 87.4 |
| Reactive arthropathy, including Reiter’s syndrome flr | B27 | 37.0 |
| Rheumatoid arthritis ra pr : polyarthrite rhumatoide | DR 4 | 4.2 |
| Behçet’s syndrome | B51 | 3.8 |
| Systemic lupus erythematosus led lead | DR 3 | 5.8 |
| Insu in-dependent (type 1) diabetes did | DR 3 | 3.3 |
| mellitus | DQB1*0201 | 2.4 |
| D 4 | 6.4 | |
| DQB1*0302 | 9.5 | |
| DR 2 | 0.19 | |
| Idiopathic Addison’s disease | DR 3 | 6.3 |
| Graves’ disease | DR 3 | 3.7 |
| Hashimoto’s disease | DR 11 | 3.2 |
| Postpartum thyroiditis | DR 4 | 5.3 |
| Celiac disease : Maladie caeliaque | DR 3 | 10.8 |
| DQB1*0201 | 6.0–10.0 | |
| DQA1*0501 | ||
| DR 7, 11 | ||
| DR 7, DQB1*0201 | ||
| DR 11, DQA1*0501 | ||
| Dermatitis herpetiformis | DR 3 | 15.9 |
| Sicca syndrome | DR 3 | 9.7 |
| Myasthenia gravis | DR 3 | 2.5 |
| B8 | 3.4 | |
| Idiopathic membranous g omeru- | DR 3 | 12.0 |
| Goodpasture’s syndrome | DR 2 | 15.9 |
| Multiple sclerosis | DR 2 | 4.1 |
| DR B1*1501 | ||
| DR B5*0101 | ||
| DQB1*0602 | ||
| Pemphigus vulgaris (among Ash-kenazi Jews) | DR 4 | 14.4 |
| Psoriasis vulgaris | Cw6 | 13.3 |
| Birdshot retinochoroidopathy | A29 | 109.0 |
*Symbols with asterisks indicate alleles, and symbols without asterisks indicate sero ogica y defined antigens. For each disease, the marker or markers with the strongest associations are given. In many cases in which it is difficu t to decide whether HLA-D or DQ markers are responsible for the association, both markers are given. †The re ative risk indicates the frequency of a disease in persons with the HLA marker as compared with persons without the marker. A positive as-sociation ( i.e., when the HLA marker is more frequent in persons with the disease than in those without it) is indicated by a re ative risk of more than 1.0, a negative association by a re ative risk of ess than 1.0, and no associ-ation by a re ative risk of 1.0. ‡The risk has not been assessed separate y for this allele.
