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PHTLS
PHTLS: Pre Hospital Trauma Life Support (PHTLS) AMLS EPC EMS Safety PHTLS About PHTLS World Trauma Symposium International PHTLS Programs TCCC Trauma Resources Trauma First Response FAQ's Course Administration Center Locate a Course Online EMS Education Purchase Textbooks

NAEMT's Prehospital Trauma Life Support (PHTLS) is recognized around the world as the leading continuing education program for prehospital emergency trauma care.

PHTLS promotes excellence in trauma patient management through global education of all providers involved in the delivery of prehospital care. PHTLS is developed by NAEMT in cooperation with the American College of Surgeons Committee on Trauma.

PHTLS courses improve the quality of trauma care in your area and decrease mortality. The program is based on a prehospital trauma care philosophy, stressing the treatment of the multi-system trauma patient as a unique entity with specific needs. This may require an approach to the trauma patient that varies from traditional treatment modalities.

PHTLS promotes critical thinking as the foundation for providing quality care. It is based on the belief that, given a good fund of knowledge and key principles, EMS providers are capable of making reasoned decisions regarding patient care. The PHTLS course is continuously updated and revised to keep up with the advances in the field, ATLS Guidelines and feedback from PHTLS participants.
Porphyromonas gingivalis
Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a non-motile, gram-negative, rod-shaped, anaerobic pathogenic bacterium. It forms black colonies on blood agar.

It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as the upper gastrointestinal tract, respiratory tract, and in the colon. Collagen degradation that is observed in chronic periodontal disease results in part from the collagenase enzymes of this species.

In patients harbouring Porphyromonas gingivalis one finds high levels of specific antibody in the serum.

Additionally Porphyromonas gingivalis has been linked to rheumatoid arthritis. Porphyromonas gingivalis contains the PAD (Peptidyl-Arginine Deaminase) which is involved in citrullination . Patients with Rheumatoid Arthritis have an increased incidence of periodontal disease and antibodies to the bacterium are significantly more common in patients with Rheumatoid Arthritis.

http://en.wikipedia.org/wiki/Porphyromonas_gingivalis
Protein-arginine deiminase
Protein-arginine deiminase

In enzymology, a protein-arginine deiminase (EC 3.5.3.15) is an enzyme that catalyzes a form of post translational modification called arginine de-imination or citrullination:

protein L-arginine + H2O \rightleftharpoons protein L-citrulline + NH3

Thus, the two substrates of this enzyme are protein L-arginine and H2O, whereas its two products are protein L-citrulline and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is protein-L-arginine iminohydrolase. This enzyme is also called peptidylarginine deiminase.

Source: http://en.wikipedia.org/wiki/Protein-arginine_deiminase
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